ncRNA name | Dll4 siRNA |
ncRNA Category | siRNA |
Disease name | choroidal neovascularization (CNV) |
Species | Macaca mulatta |
Tissues/Cell_line | rhesus choroid-retinal endothelial cell line RF/6A |
Methods | RT-PCR, qPCR, Western blot, siRNA transfection, flow cytometry, MTT assay, transwell assay, tube formation assay |
Expression pattern | associated |
Functional description | Knockdown of DLL4 expression significantly promoted the proliferation of hypoxic RF/6A cells and led to their arrest in the S phase of the cell cycle. Migration and tube formation of hypoxic RF/6A cells were significantly induced by the DLL4 siRNA, with the number of migrated cells increased by 1.6-fold and total tube length increased by 82.3%, compared with the scrambled siRNA. |
PubMed ID | 21362319 |
Year | 2011 |
Title | Effect of DLL4 siRNA on proliferation, migration and tube formation of choroid-retinal endothelial cells under hypoxic conditions. |
Drug-related ncRNA | NO |
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